PFAS | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of PFAS at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	2143.07	1808 / 1809	100%	33.24	472 / 472
esophagus	100%	1271.07	1443 / 1445	99%	18.58	181 / 183
stomach	100%	1298.86	359 / 359	99%	17.00	282 / 286
intestine	100%	1425.46	966 / 966	98%	16.87	519 / 527
prostate	100%	1567.09	245 / 245	98%	15.09	494 / 502
breast	100%	1965.46	459 / 459	98%	14.45	1094 / 1118
bladder	100%	1654.52	21 / 21	98%	14.62	493 / 504
ovary	100%	2127.63	180 / 180	98%	14.27	420 / 430
thymus	100%	1902.06	653 / 653	98%	12.25	590 / 605
lung	99%	1399.35	573 / 578	98%	14.42	1135 / 1155
uterus	100%	2035.99	170 / 170	97%	15.98	446 / 459
kidney	100%	1472.07	89 / 89	97%	15.10	875 / 901
brain	97%	1001.36	2563 / 2642	100%	22.22	702 / 705
pancreas	100%	1226.03	328 / 328	94%	9.50	168 / 178
adrenal gland	100%	1945.55	258 / 258	86%	8.60	197 / 230
liver	100%	1083.39	226 / 226	82%	8.14	331 / 406
adipose	100%	1775.93	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	29.58	80 / 80
lymph node	0%	0	0 / 0	100%	28.71	29 / 29
spleen	100%	2312.63	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.00	1 / 1
blood vessel	100%	1040.68	1332 / 1335	0%	0	0 / 0
muscle	99%	808.11	795 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	13.78	44 / 45
heart	96%	816.60	824 / 861	0%	0	0 / 0
peripheral blood	63%	1600.04	582 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0044208	Biological process	'de novo' AMP biosynthetic process
GO_0006164	Biological process	purine nucleotide biosynthetic process
GO_0009168	Biological process	purine ribonucleoside monophosphate biosynthetic process
GO_0006541	Biological process	glutamine metabolic process
GO_0006189	Biological process	'de novo' IMP biosynthetic process
GO_0006177	Biological process	GMP biosynthetic process
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0097294	Biological process	'de novo' XMP biosynthetic process
GO_0097065	Biological process	anterior head development
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005524	Molecular function	ATP binding
GO_0046872	Molecular function	metal ion binding
GO_0004642	Molecular function	phosphoribosylformylglycinamidine synthase activity

Gene name	PFAS
Protein name	Phosphoribosylformylglycinamidine synthase Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (Formylglycinamide ribotide amidotransferase) PFAS protein
Synonyms	hCG_31283 KIAA0361
Description	FUNCTION: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. .
Accessions	O15067 J3KTL4 Q9BR56 H0YGH1 J3QSG0 ENST00000580356.5 ENST00000625942.1 J3QSH6 ENST00000581242.3 B4DJ26 ENST00000583059.1 J3KT98 J3KTQ5 J3QL39 A8K8N7 Q6P4B4 ENST00000546020.2 ENST00000585183.5 ENST00000584044.5 ENST00000578979.5 ENST00000314666.11

PFAS report