PEX6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016558Biological processprotein import into peroxisome matrix
GO_0016562Biological processprotein import into peroxisome matrix, receptor recycling
GO_0043335Biological processprotein unfolding
GO_0050821Biological processprotein stabilization
GO_0007031Biological processperoxisome organization
GO_0016561Biological processprotein import into peroxisome matrix, translocation
GO_0006625Biological processprotein targeting to peroxisome
GO_0005778Cellular componentperoxisomal membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0097733Cellular componentphotoreceptor cell cilium
GO_0044877Molecular functionprotein-containing complex binding
GO_0140318Molecular functionprotein transporter activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0140036Molecular functionubiquitin-modified protein reader activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene namePEX6
Protein namePeroxisomal ATPase PEX6 (EC 3.6.4.-) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) (Peroxisome assembly factor 2) (PAF-2)
SynonymsPXAAA1
DescriptionFUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling . Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel . Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 . .

AccessionsQ13608
ENST00000244546.4 [Q13608-2]
ENST00000304611.13 [Q13608-1]