PEX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016558Biological processprotein import into peroxisome matrix
GO_0000425Biological processpexophagy
GO_0034614Biological processcellular response to reactive oxygen species
GO_0044721Biological processprotein import into peroxisome matrix, substrate release
GO_0045046Biological processprotein import into peroxisome membrane
GO_0007006Biological processmitochondrial membrane organization
GO_0007029Biological processendoplasmic reticulum organization
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0001764Biological processneuron migration
GO_0016562Biological processprotein import into peroxisome matrix, receptor recycling
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0050905Biological processneuromuscular process
GO_0021795Biological processcerebral cortex cell migration
GO_0048468Biological processcell development
GO_0016560Biological processprotein import into peroxisome matrix, docking
GO_0006635Biological processfatty acid beta-oxidation
GO_0021895Biological processcerebral cortex neuron differentiation
GO_0040018Biological processpositive regulation of multicellular organism growth
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0000268Molecular functionperoxisome targeting sequence binding
GO_0031267Molecular functionsmall GTPase binding
GO_0140597Molecular functionprotein carrier chaperone
GO_0005052Molecular functionperoxisome matrix targeting signal-1 binding
GO_0033328Molecular functionperoxisome membrane targeting sequence binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEX5
Protein namePeroxisomal biogenesis factor 5 isoform 4
Peroxisomal biogenesis factor 5 isoform 5
Peroxisomal targeting signal 1 receptor (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
Peroxisomal biogenesis factor 5
Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
SynonymsPXR1
DescriptionFUNCTION: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) . Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins . PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle . .; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 . Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal . PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 . .; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. .

AccessionsENST00000672541.1 [P50542-4]
ENST00000542539.5
ENST00000455147.6 [P50542-1]
A0A0S2Z4X8
B4E0T2
F5H3X7
F5H5C0
H0YGT8
ENST00000396637.7
ENST00000545845.1
ENST00000541850.1
ENST00000671993.1 [P50542-1]
ENST00000543974.5
ENST00000266563.9 [P50542-2]
ENST00000434354.6 [P50542-4]
ENST00000544456.5
ENST00000672242.1 [P50542-2]
ENST00000672776.1 [P50542-3]
ENST00000412720.6
ENST00000266564.7 [P50542-3]
F5GXX3
ENST00000537873.5
ENST00000420616.6 [P50542-1]
F5GYB4
ENST00000672694.1 [P50542-1]
F5H432
ENST00000545574.5
A0A0S2Z4F3
A0A0S2Z4C1
F5GZ41
F5H0L9
ENST00000536883.5
F5H637
P50542
ENST00000675855.1 [P50542-1]
A0A0S2Z4H1
J3KPV0
A0A0S2Z480
F5H205
ENST00000536841.5
ENST00000540398.5