PEX19 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PEX19 at tissue level.

III. Associated gene sets

GO_1900131Biological processnegative regulation of lipid binding
GO_0061077Biological processchaperone-mediated protein folding
GO_0045046Biological processprotein import into peroxisome membrane
GO_0050821Biological processprotein stabilization
GO_0007031Biological processperoxisome organization
GO_0016559Biological processperoxisome fission
GO_0072663Biological processestablishment of protein localization to peroxisome
GO_0006625Biological processprotein targeting to peroxisome
GO_0031526Cellular componentbrush border membrane
GO_0005778Cellular componentperoxisomal membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0036105Molecular functionperoxisome membrane class-1 targeting sequence binding
GO_0140597Molecular functionprotein carrier chaperone
GO_0051117Molecular functionATPase binding
GO_0033328Molecular functionperoxisome membrane targeting sequence binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEX19
Protein namePeroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)
Peroxisomal biogenesis factor 19
Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein)
SynonymsHK33
hCG_39731
PXF
OK/SW-cl.22
DescriptionFUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. .

FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. .

FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. .

FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. .

FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. .

AccessionsP40855
A0A0S2Z497
Q5QNY5
ENST00000462644.5
ENST00000532643.5
ENST00000495624.1
ENST00000472750.5 [P40855-6]
E9PS71
B7Z6I5
B7Z8B3
ENST00000392220.2
ENST00000368072.10 [P40855-1]
H0YDY4