PEX13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060152Biological processmicrotubule-based peroxisome localization
GO_0001561Biological processfatty acid alpha-oxidation
GO_0001764Biological processneuron migration
GO_0034614Biological processcellular response to reactive oxygen species
GO_0021795Biological processcerebral cortex cell migration
GO_0007626Biological processlocomotory behavior
GO_0016561Biological processprotein import into peroxisome matrix, translocation
GO_0016560Biological processprotein import into peroxisome matrix, docking
GO_0001967Biological processsuckling behavior
GO_0005778Cellular componentperoxisomal membrane
GO_1990429Cellular componentperoxisomal importomer complex
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0016020Cellular componentmembrane
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEX13
Protein namePeroxisomal membrane protein PEX13 (Peroxin-13)
Peroxisomal biogenesis factor 13 (Peroxisome biogenesis factor 13, isoform CRA_e)
Peroxisomal biogenesis factor 13 (Peroxisome biogenesis factor 13, isoform CRA_a)
Peroxisomal biogenesis factor 13 (Peroxisome biogenesis factor 13, isoform CRA_d)
SynonymshCG_15153
DescriptionFUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix . Involved in the import of PTS1- and PTS2-type containing proteins . .

AccessionsD3YTD3
ENST00000444100.2
B5MBY9
G5E9N6
Q92968
ENST00000414712.2
ENST00000295030.6
ENST00000401576.1