PEX12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PEX12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PEX12 at tissue level.

III. Associated gene sets

GO_0016558Biological processprotein import into peroxisome matrix
GO_0034614Biological processcellular response to reactive oxygen species
GO_0000209Biological processprotein polyubiquitination
GO_0044721Biological processprotein import into peroxisome matrix, substrate release
GO_0016562Biological processprotein import into peroxisome matrix, receptor recycling
GO_0007031Biological processperoxisome organization
GO_0006625Biological processprotein targeting to peroxisome
GO_0006513Biological processprotein monoubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0005778Cellular componentperoxisomal membrane
GO_0005777Cellular componentperoxisome
GO_1990429Cellular componentperoxisomal importomer complex
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_1990757Molecular functionubiquitin ligase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEX12
Protein namePeroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3)
Peroxisomal biogenesis factor 12
PEX12 protein
Peroxisome assembly protein 12 (Peroxin-12)
SynonymsPAF3
DescriptionFUNCTION: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling . The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 . When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity). .

FUNCTION: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. .

AccessionsA0PJ54
ENST00000586663.2
K7ELY8
ENST00000585380.1
A0A075B773
ENST00000225873.9
O00623