PEX10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PEX10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PEX10 at tissue level.

III. Associated gene sets

GO_0016558Biological processprotein import into peroxisome matrix
GO_0034614Biological processcellular response to reactive oxygen species
GO_0016562Biological processprotein import into peroxisome matrix, receptor recycling
GO_0000209Biological processprotein polyubiquitination
GO_0007031Biological processperoxisome organization
GO_0044721Biological processprotein import into peroxisome matrix, substrate release
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0005778Cellular componentperoxisomal membrane
GO_0005777Cellular componentperoxisome
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene namePEX10
Protein namePeroxisomal biogenesis factor 10
Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
SynonymsRNF69
DescriptionFUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling . The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase . When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity). .

AccessionsENST00000510434.1
J3QRM4
ENST00000514502.1
ENST00000447513.7 [O60683-1]
D6RBB0
Q6FGN0
A0A3B3ITN6
ENST00000508384.5
ENST00000288774.8 [O60683-2]
J3KRE0
D6RA89
ENST00000502666.1
D6RIF5
ENST00000650293.1
ENST00000507596.5
O60683