PEMT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0006686Biological processsphingomyelin biosynthetic process
GO_0001835Biological processblastocyst hatching
GO_0032259Biological processmethylation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031966Cellular componentmitochondrial membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0080101Molecular functionphosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO_0004608Molecular functionphosphatidylethanolamine N-methyltransferase activity
GO_0000773Molecular functionphosphatidyl-N-methylethanolamine N-methyltransferase activity

IV. Literature review

[source]
Gene namePEMT
Protein namePhosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT)
Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (Phospholipid methyltransferase) (PLMT)
Phosphatidylethanolamine N-methyltransferase
SynonymsPNMT
PEMPT
DescriptionFUNCTION: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step. .

FUNCTION: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure . Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step . Responsible for approximately 30% of hepatic PC with the CDP-choline pathway accounting for the other 70% (Probable). .; FUNCTION: [Isoform 1]: Catalyzes the three sequential steps of the methylation of 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine (PMME) to 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine (PDME) more efficiently than isoform 2 . Induces increase in PC species with longer polyunsaturated chains than isoform 2 . .; FUNCTION: [Isoform 2]: Produces a higher increase in the level of PC species containing long chains with three double bonds than isoform 1. .

FUNCTION: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step. .

AccessionsENST00000255389.10 [Q9UBM1-2]
ENST00000580147.5
ENST00000395782.5 [Q9UBM1-1]
D3YTC7
ENST00000435340.6
Q9UBM1
J3QLU8
ENST00000395783.5 [Q9UBM1-1]
J3KTR2
ENST00000395781.6 [Q9UBM1-3]
Q71UY0
ENST00000461404.1