PDYN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PDYN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDYN at tissue level.

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0007600Biological processsensory perception
GO_0007268Biological processchemical synaptic transmission
GO_0098992Cellular componentneuronal dense core vesicle
GO_0043679Cellular componentaxon terminus
GO_0005576Cellular componentextracellular region
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0030425Cellular componentdendrite
GO_0031628Molecular functionopioid receptor binding
GO_0001515Molecular functionopioid peptide activity

IV. Literature review

[source]
Gene namePDYN
Protein nameProenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin)
Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)]
Prodynorphin
Preprodynorphin
Synonyms
DescriptionFUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). .; FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity). .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. .; FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. .

AccessionsQ2YEL0
Q2YEM6
A0A494C197
ENST00000540134.5
ENST00000652436.1
ENST00000651882.1
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A0A494C1E3
A0A494C1U2
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ENST00000539905.5
A0A494C0X3
ENST00000651996.1
A0A494C0Y8
P01213
ENST00000650874.1
A0A494C0B1
A0A494C1J4
ENST00000217305.3
ENST00000650937.1
ENST00000651328.1
ENST00000650824.1