PDXP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PDXP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDXP at tissue level.

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0032361Biological processpyridoxal phosphate catabolic process
GO_0071318Biological processcellular response to ATP
GO_0016311Biological processdephosphorylation
GO_0031247Biological processactin rod assembly
GO_0030836Biological processpositive regulation of actin filament depolymerization
GO_0032465Biological processregulation of cytokinesis
GO_0007088Biological processregulation of mitotic nuclear division
GO_0032587Cellular componentruffle membrane
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0070938Cellular componentcontractile ring
GO_0015629Cellular componentactin cytoskeleton
GO_0031258Cellular componentlamellipodium membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0032154Cellular componentcleavage furrow
GO_0030027Cellular componentlamellipodium
GO_0042803Molecular functionprotein homodimerization activity
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0031072Molecular functionheat shock protein binding
GO_0033883Molecular functionpyridoxal phosphatase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDXP
Protein nameChronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase)
Pyridoxal phosphatase
Pyridoxal (Pyridoxine, vitamin B6) phosphatase, isoform CRA_a (Testicular secretory protein Li 36)
SynonymsPLPP
CIN
PLP
hCG_41847
DescriptionFUNCTION: Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism . Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine . .

AccessionsENST00000403251.1
A0A024R1I3
Q96GD0
B1AHD3
ENST00000215904.7 [Q96GD0-1]