PDSS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008299Biological processisoprenoid biosynthetic process
GO_0006744Biological processubiquinone biosynthetic process
GO_0032478Cellular componentheterotetrameric polyprenyl diphosphate synthase complex
GO_0005759Cellular componentmitochondrial matrix
GO_1990234Cellular componenttransferase complex
GO_0046982Molecular functionprotein heterodimerization activity
GO_0052923Molecular functionall-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0004659Molecular functionprenyltransferase activity
GO_0097269Molecular functionall-trans-decaprenyl-diphosphate synthase activity

IV. Literature review

[source]
Gene namePDSS1
Protein nameDecaprenyl diphosphate synthase subunit 1
All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl pyrophosphate synthase subunit 1) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1)
SynonymsTPRT
DPS1
DescriptionFUNCTION: Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone . Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively . The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry . .

AccessionsQ5T2R2
ENST00000491711.5
ENST00000376215.10 [Q5T2R2-1]
H0YEE6