PDE6B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_1990009Biological processretinal cell apoptotic process
GO_0019933Biological processcAMP-mediated signaling
GO_0007603Biological processphototransduction, visible light
GO_0060041Biological processretina development in camera-type eye
GO_0042622Cellular componentphotoreceptor outer segment membrane
GO_0097381Cellular componentphotoreceptor disc membrane
GO_0005886Cellular componentplasma membrane
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePDE6B
Protein namePhosphodiesterase 6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)
SynonymsPDEB
DescriptionFUNCTION: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP . Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal . .

AccessionsENST00000465426.5
ENST00000461490.1
C9J628
ENST00000255622.10 [P35913-2]
H7C4P9
ENST00000429163.6 [P35913-3]
C9J7V6
ENST00000471824.6
ENST00000496514.6 [P35913-1]
H7C4F7
P35913
ENST00000487902.5