PDE1B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDE1B at tissue level.

III. Associated gene sets

GO_0001975Biological processresponse to amphetamine
GO_0019933Biological processcAMP-mediated signaling
GO_0036006Biological processcellular response to macrophage colony-stimulating factor stimulus
GO_0042428Biological processserotonin metabolic process
GO_0030224Biological processmonocyte differentiation
GO_0007626Biological processlocomotory behavior
GO_0008542Biological processvisual learning
GO_0042420Biological processdopamine catabolic process
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_0005829Cellular componentcytosol
GO_0043025Cellular componentneuronal cell body
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0004117Molecular functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0048101Molecular functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePDE1B
Protein namePhosphodiesterase 1B
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
Phosphodiesterase (EC 3.1.4.-)
SynonymsPDES1B
DescriptionFUNCTION: Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has a preference for cGMP as a substrate . .

AccessionsENST00000550285.5
A0A087WTW8
ENST00000550620.1 [Q01064-2]
F8VZK3
ENST00000243052.8 [Q01064-1]
ENST00000538346.5
Q01064
B4DK72
ENST00000611899.4