PDE12 | OmnibusX

Name	Number of supported studies	Average coverage
peripheral blood	3 studies	20% ± 3%	Explore
brain	3 studies	33% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1684.58	1445 / 1445	100%	15.97	183 / 183
intestine	100%	1538.93	966 / 966	100%	15.76	527 / 527
ovary	100%	1253.69	180 / 180	100%	11.35	430 / 430
stomach	100%	1404.90	359 / 359	100%	17.40	286 / 286
breast	100%	1450.79	459 / 459	100%	16.28	1116 / 1118
brain	100%	1241.59	2637 / 2642	100%	14.15	705 / 705
lung	100%	1406.14	577 / 578	100%	11.75	1154 / 1155
bladder	100%	1563.81	21 / 21	100%	12.29	502 / 504
prostate	100%	1414.47	245 / 245	100%	14.20	500 / 502
liver	100%	1422.65	226 / 226	99%	8.86	403 / 406
thymus	100%	1452.10	652 / 653	99%	11.97	601 / 605
uterus	100%	1417.51	170 / 170	99%	10.19	454 / 459
pancreas	100%	927.51	327 / 328	99%	10.34	176 / 178
adrenal gland	100%	2535.31	258 / 258	98%	12.80	226 / 230
kidney	100%	1167.28	89 / 89	97%	9.84	874 / 901
skin	100%	1688.39	1809 / 1809	96%	14.79	454 / 472
adipose	100%	1596.92	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1393.69	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	13.57	29 / 29
muscle	100%	1226.55	803 / 803	0%	0	0 / 0
spleen	100%	1428.87	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.62	45 / 45
ureter	0%	0	0 / 0	100%	7.87	1 / 1
heart	98%	943.26	840 / 861	0%	0	0 / 0
peripheral blood	79%	897.04	734 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	65%	4.17	52 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0044528	Biological process	regulation of mitochondrial mRNA stability
GO_0090304	Biological process	nucleic acid metabolic process
GO_0035457	Biological process	cellular response to interferon-alpha
GO_0006397	Biological process	mRNA processing
GO_0051607	Biological process	defense response to virus
GO_0071359	Biological process	cellular response to dsRNA
GO_0045070	Biological process	positive regulation of viral genome replication
GO_0071346	Biological process	cellular response to type II interferon
GO_0000958	Biological process	mitochondrial mRNA catabolic process
GO_0000288	Biological process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0140374	Biological process	antiviral innate immune response
GO_0005739	Cellular component	mitochondrion
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0004527	Molecular function	exonuclease activity
GO_0034611	Molecular function	oligoribonucleotidase activity
GO_0046872	Molecular function	metal ion binding
GO_0000175	Molecular function	3'-5'-RNA exonuclease activity
GO_0004535	Molecular function	poly(A)-specific ribonuclease activity

Gene name	PDE12
Protein name	2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) Phosphodiesterase 12
Synonyms
Description	FUNCTION: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP . Also cleaves 3',5'-phosphodiester bond of oligoadenylates . Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells . .
Accessions	ENST00000487257.1 ENST00000311180.9 [Q6L8Q7-1] Q6L8Q7 F6T1Q0

PDE12 report