Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 39% ± 17% | |
| glutamatergic neuron | 12 studies | 57% ± 19% | |
| pericyte | 10 studies | 29% ± 12% | |
| GABAergic neuron | 10 studies | 54% ± 23% | |
| oligodendrocyte precursor cell | 7 studies | 25% ± 6% | |
| interneuron | 6 studies | 48% ± 27% | |
| fibroblast | 6 studies | 20% ± 6% | |
| oligodendrocyte | 6 studies | 28% ± 21% | |
| neuron | 4 studies | 40% ± 9% | |
| granule cell | 4 studies | 48% ± 28% | |
| cardiac muscle cell | 4 studies | 32% ± 12% | |
| smooth muscle cell | 4 studies | 24% ± 8% | |
| mesothelial cell | 4 studies | 42% ± 7% | |
| GABAergic interneuron | 3 studies | 59% ± 8% | |
| endothelial cell of artery | 3 studies | 31% ± 12% | |
| vein endothelial cell | 3 studies | 46% ± 20% | |
| Mueller cell | 3 studies | 54% ± 22% | |
| amacrine cell | 3 studies | 34% ± 16% | |
| glycinergic amacrine cell | 3 studies | 32% ± 13% | |
| endothelial cell of vascular tree | 3 studies | 37% ± 18% | |
| connective tissue cell | 3 studies | 23% ± 8% | |
| astrocyte | 3 studies | 41% ± 26% | |
| renal principal cell | 3 studies | 53% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 85% | 409.57 | 219 / 258 | 77% | 5.20 | 177 / 230 |
| prostate | 98% | 728.68 | 239 / 245 | 60% | 1.96 | 299 / 502 |
| thymus | 100% | 1424.03 | 651 / 653 | 55% | 2.00 | 334 / 605 |
| kidney | 100% | 1066.37 | 89 / 89 | 52% | 3.04 | 466 / 901 |
| brain | 97% | 2347.22 | 2574 / 2642 | 47% | 1.01 | 331 / 705 |
| breast | 99% | 969.85 | 456 / 459 | 39% | 1.11 | 438 / 1118 |
| bladder | 95% | 612.00 | 20 / 21 | 42% | 2.15 | 214 / 504 |
| uterus | 98% | 958.92 | 167 / 170 | 32% | 1.47 | 147 / 459 |
| lung | 88% | 408.48 | 509 / 578 | 32% | 1.28 | 366 / 1155 |
| stomach | 84% | 383.48 | 302 / 359 | 23% | 0.66 | 67 / 286 |
| ovary | 99% | 1101.39 | 179 / 180 | 6% | 0.28 | 26 / 430 |
| esophagus | 66% | 247.66 | 958 / 1445 | 37% | 0.95 | 67 / 183 |
| spleen | 99% | 505.58 | 239 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 851.78 | 1187 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 691.31 | 844 / 861 | 0% | 0 | 0 / 0 |
| skin | 21% | 55.58 | 379 / 1809 | 76% | 3.46 | 357 / 472 |
| intestine | 74% | 322.34 | 719 / 966 | 19% | 0.47 | 99 / 527 |
| blood vessel | 88% | 446.33 | 1179 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 73% | 2.44 | 58 / 80 |
| pancreas | 29% | 69.06 | 94 / 328 | 43% | 0.93 | 76 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 0.78 | 12 / 45 |
| muscle | 16% | 38.19 | 129 / 803 | 0% | 0 | 0 / 0 |
| liver | 6% | 13.54 | 14 / 226 | 7% | 0.21 | 28 / 406 |
| peripheral blood | 0% | 1.87 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019933 | Biological process | cAMP-mediated signaling |
| GO_0010754 | Biological process | negative regulation of cGMP-mediated signaling |
| GO_0006198 | Biological process | cAMP catabolic process |
| GO_0046069 | Biological process | cGMP catabolic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0047555 | Molecular function | 3',5'-cyclic-GMP phosphodiesterase activity |
| GO_0004114 | Molecular function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| GO_0004115 | Molecular function | 3',5'-cyclic-AMP phosphodiesterase activity |
| GO_0030552 | Molecular function | cAMP binding |
| GO_0030553 | Molecular function | cGMP binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0004118 | Molecular function | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity |
| Gene name | PDE10A |
| Protein name | Phosphodiesterase 10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) Phosphodiesterase (EC 3.1.4.-) |
| Synonyms | hCG_34059 PDE10A19 |
| Description | FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides . Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate . May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition . . |
| Accessions | ENST00000648884.1 A0A3B3IRL3 ENST00000648917.1 A0A3B3IS50 ENST00000672902.1 ENST00000539869.4 [Q9Y233-3] A0A5F9ZHF9 A0A087WUD0 ENST00000676766.1 ENST00000676767.1 ENST00000678161.1 A0A1B1UZQ1 ENST00000647590.1 A0A3B3ITT8 ENST00000616273.1 A0A3B3IRU7 A0A7I2V301 ENST00000647837.1 Q9Y233 A0A7I2V618 A0A1B1UZR0 ENST00000647768.3 A0A5F9ZI67 ENST00000672859.1 A0A7I2YQI4 A0A3B3IT18 ENST00000649247.1 ENST00000678462.1 A0A7I2YQV2 ENST00000649273.1 A0A3B3ISJ6 |