PDE10A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019933Biological processcAMP-mediated signaling
GO_0010754Biological processnegative regulation of cGMP-mediated signaling
GO_0006198Biological processcAMP catabolic process
GO_0046069Biological processcGMP catabolic process
GO_0005829Cellular componentcytosol
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0004114Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0030552Molecular functioncAMP binding
GO_0030553Molecular functioncGMP binding
GO_0046872Molecular functionmetal ion binding
GO_0004118Molecular functioncGMP-stimulated cyclic-nucleotide phosphodiesterase activity

IV. Literature review

[source]
Gene namePDE10A
Protein namePhosphodiesterase 10A
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17)
Phosphodiesterase (EC 3.1.4.-)
SynonymshCG_34059
PDE10A19
DescriptionFUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides . Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate . May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition . .

AccessionsENST00000648884.1
A0A3B3IRL3
ENST00000648917.1
A0A3B3IS50
ENST00000672902.1
ENST00000539869.4 [Q9Y233-3]
A0A5F9ZHF9
A0A087WUD0
ENST00000676766.1
ENST00000676767.1
ENST00000678161.1
A0A1B1UZQ1
ENST00000647590.1
A0A3B3ITT8
ENST00000616273.1
A0A3B3IRU7
A0A7I2V301
ENST00000647837.1
Q9Y233
A0A7I2V618
A0A1B1UZR0
ENST00000647768.3
A0A5F9ZI67
ENST00000672859.1
A0A7I2YQI4
A0A3B3IT18
ENST00000649247.1
ENST00000678462.1
A0A7I2YQV2
ENST00000649273.1
A0A3B3ISJ6