PCSK4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PCSK4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PCSK4 at tissue level.

III. Associated gene sets

GO_0016486Biological processpeptide hormone processing
GO_0007339Biological processbinding of sperm to zona pellucida
GO_0016485Biological processprotein processing
GO_0009566Biological processfertilization
GO_0048240Biological processsperm capacitation
GO_0022414Biological processreproductive process
GO_0007340Biological processacrosome reaction
GO_0005802Cellular componenttrans-Golgi network
GO_0002080Cellular componentacrosomal membrane
GO_0000139Cellular componentGolgi membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePCSK4
Protein nameProprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4)
Proprotein convertase subtilisin/kexin type 4
SynonymsUNQ2757/PRO6496
PC4
DescriptionFUNCTION: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 . May also participate in folliculogenesis in the ovaries (By similarity). .

AccessionsENST00000591201.5
K7EN14
ENST00000588671.2
Q6UW60
K7EJB6
ENST00000300954.10 [Q6UW60-1]