PCCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019626Biological processshort-chain fatty acid catabolic process
GO_0009081Biological processbranched-chain amino acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_1902494Cellular componentcatalytic complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004658Molecular functionpropionyl-CoA carboxylase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePCCB
Protein namePropionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)
Propionyl-CoA carboxylase subunit beta
Propionyl-CoA carboxylase beta chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)
SynonymshCG_15235
DescriptionFUNCTION: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites . Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA . Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate . Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). .

AccessionsENST00000482086.5
A0A1B2JLU8
C9JVW9
E9PEC3
Q9HBR7
ENST00000462637.5
ENST00000484181.5
ENST00000459873.1
E7EUY3
ENST00000494742.5
ENST00000466072.5
ENST00000483687.5
E7ENC1
H7C5C9
C9JVY9
C9JQS9
C9JAW3
F8WBI9
E7ETT4
P05166
ENST00000465423.5
ENST00000490504.5
ENST00000462542.5
E9PDR0
ENST00000469217.5 [P05166-2]
ENST00000478469.5
ENST00000251654.9 [P05166-1]
ENST00000468777.5
ENST00000471595.5
E7ETT1
E7EX59