Name | Number of supported studies | Average coverage | |
---|---|---|---|
transit amplifying cell | 3 studies | 26% ± 6% |
Insufficient scRNA-seq data for expression of PBK at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 90% | 784.51 | 1630 / 1809 | 93% | 39.56 | 438 / 472 |
intestine | 52% | 172.09 | 507 / 966 | 95% | 34.69 | 499 / 527 |
esophagus | 41% | 221.93 | 597 / 1445 | 99% | 38.78 | 182 / 183 |
stomach | 44% | 127.35 | 157 / 359 | 96% | 36.00 | 275 / 286 |
lung | 39% | 77.99 | 224 / 578 | 82% | 23.97 | 945 / 1155 |
bladder | 14% | 15.90 | 3 / 21 | 90% | 27.42 | 454 / 504 |
uterus | 6% | 8.85 | 11 / 170 | 97% | 39.23 | 446 / 459 |
breast | 13% | 14.31 | 60 / 459 | 88% | 25.72 | 982 / 1118 |
lymph node | 0% | 0 | 0 / 0 | 100% | 28.53 | 29 / 29 |
tonsil | 0% | 0 | 0 / 0 | 100% | 53.24 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.12 | 1 / 1 |
ovary | 5% | 16.18 | 9 / 180 | 95% | 26.14 | 407 / 430 |
spleen | 78% | 143.37 | 189 / 241 | 0% | 0 | 0 / 0 |
adrenal gland | 35% | 50.50 | 90 / 258 | 39% | 10.70 | 89 / 230 |
pancreas | 8% | 6.16 | 25 / 328 | 59% | 8.11 | 105 / 178 |
liver | 16% | 49.40 | 37 / 226 | 48% | 8.05 | 194 / 406 |
brain | 2% | 1.43 | 40 / 2642 | 62% | 23.07 | 439 / 705 |
peripheral blood | 33% | 555.29 | 305 / 929 | 0% | 0 | 0 / 0 |
kidney | 16% | 31.80 | 14 / 89 | 15% | 2.06 | 134 / 901 |
prostate | 14% | 15.79 | 34 / 245 | 16% | 2.07 | 82 / 502 |
adipose | 29% | 25.17 | 352 / 1204 | 0% | 0 | 0 / 0 |
thymus | 11% | 9.29 | 72 / 653 | 16% | 5.49 | 95 / 605 |
eye | 0% | 0 | 0 / 0 | 18% | 1.75 | 14 / 80 |
heart | 8% | 9.38 | 71 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 7% | 5.90 | 92 / 1335 | 0% | 0 | 0 / 0 |
muscle | 4% | 2.73 | 33 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051403 | Biological process | stress-activated MAPK cascade |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0032873 | Biological process | negative regulation of stress-activated MAPK cascade |
GO_0050728 | Biological process | negative regulation of inflammatory response |
GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0000278 | Biological process | mitotic cell cycle |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0034644 | Biological process | cellular response to UV |
GO_0005634 | Cellular component | nucleus |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0004708 | Molecular function | MAP kinase kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | PBK |
Protein name | PDZ binding kinase Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) |
Synonyms | TOPK |
Description | FUNCTION: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. . |
Accessions | ENST00000524266.1 E5RIE1 ENST00000301905.9 [Q96KB5-1] E5RFX4 ENST00000522944.5 [Q96KB5-2] Q96KB5 ENST00000521226.2 |