PAPSS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050428Biological process3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO_0060348Biological processbone development
GO_0007596Biological processblood coagulation
GO_0042445Biological processhormone metabolic process
GO_0000103Biological processsulfate assimilation
GO_0005829Cellular componentcytosol
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0004781Molecular functionsulfate adenylyltransferase (ATP) activity
GO_0004020Molecular functionadenylylsulfate kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePAPSS2
Protein nameBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b (Epididymis secretory sperm binding protein) (cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNA)
SynonymshCG_23331
ATPSK2
DescriptionFUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases . In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway . Plays indirectly an important role in skeletogenesis during postnatal growth . .

AccessionsENST00000456849.2 [O95340-2]
O95340
ENST00000361175.8 [O95340-1]
Q5TB52