PAN2 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	20% ± 3%	Explore
astrocyte	3 studies	20% ± 3%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5320.53	1445 / 1445	99%	15.03	181 / 183
lung	100%	5527.93	577 / 578	99%	13.10	1139 / 1155
stomach	100%	5537.39	359 / 359	98%	12.25	281 / 286
intestine	100%	6699.41	966 / 966	98%	12.02	515 / 527
skin	100%	4335.90	1803 / 1809	97%	13.58	459 / 472
thymus	100%	15414.14	653 / 653	97%	17.42	585 / 605
ovary	100%	10773.72	180 / 180	96%	14.83	414 / 430
kidney	100%	6480.09	89 / 89	96%	16.65	867 / 901
pancreas	100%	5496.43	328 / 328	96%	14.42	171 / 178
bladder	100%	6301.76	21 / 21	96%	13.23	483 / 504
breast	100%	6679.87	459 / 459	96%	12.87	1068 / 1118
prostate	100%	7540.42	245 / 245	94%	11.43	474 / 502
adrenal gland	100%	6820.04	257 / 258	93%	12.16	215 / 230
brain	94%	4352.77	2474 / 2642	99%	19.07	698 / 705
uterus	100%	7975.58	170 / 170	92%	12.02	423 / 459
liver	100%	7351.99	225 / 226	87%	9.57	352 / 406
spleen	100%	8712.02	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.68	1 / 1
adipose	100%	5382.26	1203 / 1204	0%	0	0 / 0
blood vessel	99%	4089.76	1328 / 1335	0%	0	0 / 0
heart	98%	4013.28	843 / 861	0%	0	0 / 0
muscle	98%	3362.34	784 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	95%	9.77	76 / 80
tonsil	0%	0	0 / 0	93%	11.74	42 / 45
lymph node	0%	0	0 / 0	76%	10.51	22 / 29
peripheral blood	49%	1771.95	456 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0000289	Biological process	nuclear-transcribed mRNA poly(A) tail shortening
GO_0010606	Biological process	positive regulation of cytoplasmic mRNA processing body assembly
GO_0006397	Biological process	mRNA processing
GO_0000932	Cellular component	P-body
GO_0031251	Cellular component	PAN complex
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0000175	Molecular function	3'-5'-RNA exonuclease activity
GO_0004535	Molecular function	poly(A)-specific ribonuclease activity
GO_0003676	Molecular function	nucleic acid binding
GO_0005515	Molecular function	protein binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0046872	Molecular function	metal ion binding

Gene name	PAN2
Protein name	PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) Poly(A) specific ribonuclease subunit PAN2
Synonyms	USP52 KIAA0710
Description	FUNCTION: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. .
Accessions	Q504Q3 ENST00000548043.5 [Q504Q3-1] ENST00000425394.7 [Q504Q3-1] F8VXK8 ENST00000547572.1 ENST00000440411.8 [Q504Q3-2] ENST00000610546.4 [Q504Q3-1] ENST00000257931.9 [Q504Q3-3]

PAN2 report