PAM16 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PAM16 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAM16 at tissue level.

III. Associated gene sets

GO_0030150Biological processprotein import into mitochondrial matrix
GO_0001503Biological processossification
GO_0006886Biological processintracellular protein transport
GO_0032780Biological processnegative regulation of ATP-dependent activity
GO_0001405Cellular componentPAM complex, Tim23 associated import motor
GO_0032991Cellular componentprotein-containing complex
GO_0099617Cellular componentmatrix side of mitochondrial inner membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005744Cellular componentTIM23 mitochondrial import inner membrane translocase complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAM16
Protein nameCoronin
Mitochondrial import inner membrane translocase subunit TIM16 (Presequence translocase associated motor 16)
Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16)
HCG15164, isoform CRA_a (Mitochondrial import inner membrane translocase subunit TIM16) (Presequence translocase associated motor 16)
HCG15164, isoform CRA_b (Mitochondrial import inner membrane translocase subunit TIM16) (Presequence translocase associated motor 16)
SynonymsTIMM16
MAGMAS
hCG_15164
TIM16
CGI-136
CORO7-PAM16
DescriptionFUNCTION: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. .

FUNCTION: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. .

AccessionsENST00000634045.1
A0A0A6YYL4
ENST00000631595.1
ENST00000575636.5
I3L3T0
ENST00000633558.1
ENST00000631739.1
ENST00000633650.1
ENST00000577031.5
ENST00000617295
ENST00000318059.8
ENST00000571941.5
ENST00000573553.5
I3L0X9
A0A0B4J298
ENST00000571986.5
I3L3G8
Q9Y3D7
ENST00000575848.5
I3L1K9
ENST00000633944.1
ENST00000616009.2
I3L1U7
ENST00000633831.1
ENST00000634029.1
ENST00000572467
ENST00000576217.1
ENST00000571178.1