PAK1IP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAK1IP1 at tissue level.

III. Associated gene sets

GO_0060021Biological processroof of mouth development
GO_0042273Biological processribosomal large subunit biogenesis
GO_0008283Biological processcell population proliferation
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0009968Biological processnegative regulation of signal transduction
GO_0005730Cellular componentnucleolus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAK1IP1
Protein namePAK1 interacting protein 1 isoform 4 (PAK1 interacting protein 1, isoform CRA_c)
PAK1 interacting protein 1 isoform 1
p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)
SynonymshCG_1782977
WDR84
PIP1
DescriptionFUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly . .

AccessionsA0A0S2Z5C3
Q9NWT1
ENST00000379568.4
ENST00000644756.2
A0A0S2Z5D3