PAGR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PAGR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAGR1 at tissue level.

III. Associated gene sets

GO_0006310Biological processDNA recombination
GO_0006281Biological processDNA repair
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0033148Biological processpositive regulation of intracellular estrogen receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0044666Cellular componentMLL3/4 complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0030331Molecular functionnuclear estrogen receptor binding

IV. Literature review

[source]
Gene namePAGR1
Protein namePAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1)
SynonymsPA1
C16orf53
DescriptionFUNCTION: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex . However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition . Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent . .

AccessionsQ9BTK6
ENST00000320330.8