PACRG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034620Biological processcellular response to unfolded protein
GO_0008104Biological processprotein localization
GO_0007286Biological processspermatid development
GO_0002177Cellular componentmanchette
GO_0043005Cellular componentneuron projection
GO_0160112Cellular componentaxonemal B tubule inner sheath
GO_0005879Cellular componentaxonemal microtubule
GO_0005829Cellular componentcytosol
GO_0044297Cellular componentcell body
GO_0097225Cellular componentsperm midpiece
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0048487Molecular functionbeta-tubulin binding
GO_0051879Molecular functionHsp90 protein binding
GO_0031072Molecular functionheat shock protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003779Molecular functionactin binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0030544Molecular functionHsp70 protein binding

IV. Literature review

[source]
Gene namePACRG
Protein nameParkin coregulated gene protein (Molecular chaperone/chaperonin-binding protein) (PARK2 coregulated gene protein)
Parkin coregulated
SynonymsGLUP
DescriptionFUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating . Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease . .

AccessionsENST00000366889.6 [Q96M98-2]
H0YFE8
ENST00000366888.7 [Q96M98-2]
ENST00000337019.7 [Q96M98-1]
ENST00000534958.5
Q96M98
ENST00000542936.1
H0YGE0
ENST00000541974.5
H0YFW3