I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 7 studies | 29% ± 10% | |
| oligodendrocyte precursor cell | 4 studies | 30% ± 4% | |
| dendritic cell | 3 studies | 28% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 7 studies | 29% ± 10% | |
| oligodendrocyte precursor cell | 4 studies | 30% ± 4% | |
| dendritic cell | 3 studies | 28% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1321.97 | 2642 / 2642 | 100% | 48.56 | 705 / 705 |
| bladder | 100% | 274.19 | 21 / 21 | 99% | 17.35 | 498 / 504 |
| breast | 99% | 311.09 | 454 / 459 | 100% | 18.16 | 1116 / 1118 |
| uterus | 99% | 302.39 | 169 / 170 | 99% | 17.77 | 454 / 459 |
| esophagus | 99% | 282.95 | 1434 / 1445 | 99% | 12.42 | 181 / 183 |
| lung | 100% | 442.20 | 577 / 578 | 98% | 18.29 | 1135 / 1155 |
| prostate | 99% | 284.30 | 243 / 245 | 98% | 13.10 | 494 / 502 |
| skin | 99% | 328.14 | 1788 / 1809 | 98% | 23.76 | 462 / 472 |
| pancreas | 98% | 221.88 | 322 / 328 | 97% | 9.70 | 173 / 178 |
| intestine | 99% | 256.25 | 952 / 966 | 97% | 11.88 | 510 / 527 |
| kidney | 100% | 495.66 | 89 / 89 | 88% | 8.31 | 791 / 901 |
| stomach | 91% | 163.78 | 328 / 359 | 95% | 11.54 | 273 / 286 |
| ovary | 92% | 181.77 | 165 / 180 | 94% | 11.10 | 403 / 430 |
| thymus | 99% | 241.97 | 644 / 653 | 81% | 6.67 | 492 / 605 |
| adrenal gland | 97% | 284.99 | 250 / 258 | 73% | 6.29 | 169 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 23.99 | 29 / 29 |
| spleen | 100% | 592.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.87 | 1 / 1 |
| adipose | 99% | 336.86 | 1193 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 12.81 | 44 / 45 |
| blood vessel | 97% | 257.77 | 1296 / 1335 | 0% | 0 | 0 / 0 |
| liver | 45% | 68.32 | 102 / 226 | 52% | 3.90 | 210 / 406 |
| peripheral blood | 92% | 447.44 | 852 / 929 | 0% | 0 | 0 / 0 |
| heart | 90% | 173.54 | 777 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 80% | 10.65 | 64 / 80 |
| muscle | 76% | 129.37 | 613 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0006821 | Biological process | chloride transport |
| GO_0009986 | Cellular component | cell surface |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0061797 | Molecular function | pH-gated chloride channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PACC1 |
| Protein name | Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) |
| Synonyms | C1orf75 TMEM206 |
| Description | FUNCTION: Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH . Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling . . |
| Accessions | ENST00000261455.9 [Q9H813-1] Q9H813 ENST00000535273.2 [Q9H813-2] |
