I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 4 studies | 19% ± 3% | |
| pericyte | 4 studies | 17% ± 1% | |
| epithelial cell | 3 studies | 21% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 4 studies | 19% ± 3% | |
| pericyte | 4 studies | 17% ± 1% | |
| epithelial cell | 3 studies | 21% ± 1% |
Insufficient scRNA-seq data for expression of PABIR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 2262.96 | 459 / 459 | 100% | 17.42 | 1118 / 1118 |
| stomach | 100% | 1305.29 | 359 / 359 | 100% | 12.47 | 286 / 286 |
| esophagus | 100% | 1579.91 | 1444 / 1445 | 100% | 15.61 | 183 / 183 |
| prostate | 100% | 1739.88 | 245 / 245 | 100% | 18.19 | 501 / 502 |
| ovary | 100% | 1746.64 | 180 / 180 | 100% | 12.11 | 429 / 430 |
| lung | 100% | 1608.51 | 578 / 578 | 100% | 13.04 | 1152 / 1155 |
| brain | 100% | 1115.42 | 2633 / 2642 | 100% | 16.70 | 705 / 705 |
| intestine | 100% | 1685.40 | 966 / 966 | 100% | 11.88 | 525 / 527 |
| skin | 100% | 1588.47 | 1809 / 1809 | 100% | 12.51 | 470 / 472 |
| adrenal gland | 100% | 2051.84 | 258 / 258 | 100% | 22.01 | 229 / 230 |
| uterus | 100% | 2184.12 | 170 / 170 | 100% | 12.68 | 457 / 459 |
| thymus | 100% | 1936.69 | 653 / 653 | 100% | 17.94 | 602 / 605 |
| pancreas | 100% | 1107.01 | 327 / 328 | 99% | 13.49 | 177 / 178 |
| kidney | 100% | 1534.85 | 89 / 89 | 99% | 16.15 | 893 / 901 |
| bladder | 100% | 1610.57 | 21 / 21 | 98% | 10.42 | 496 / 504 |
| liver | 100% | 1000.32 | 226 / 226 | 94% | 7.29 | 383 / 406 |
| adipose | 100% | 2120.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2575.65 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.18 | 29 / 29 |
| spleen | 100% | 1870.18 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.73 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.64 | 1 / 1 |
| muscle | 100% | 1134.48 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 1265.56 | 856 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 12.65 | 79 / 80 |
| peripheral blood | 93% | 910.89 | 866 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0004865 | Molecular function | protein serine/threonine phosphatase inhibitor activity |
| Gene name | PABIR1 |
| Protein name | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) |
| Synonyms | FAM122A C9orf42 |
| Description | FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity . Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) . Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint . . |
| Accessions | Q96E09 ENST00000394264.7 |
