PAAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0000502Cellular componentproteasome complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAAF1
Protein nameProteasomal ATPase associated factor 1
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
SynonymsWDR71
DescriptionFUNCTION: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. .

AccessionsENST00000546039.5
F5H103
Q9BRP4
F5H3I1
ENST00000536582.5
ENST00000543814.5
H0YGB1
F5H5D4
ENST00000542293.5
ENST00000541951.5 [Q9BRP4-3]
ENST00000310571.8 [Q9BRP4-1]
ENST00000504441.6
F5H0F7
ENST00000535604.5 [Q9BRP4-3]
ENST00000536003.5 [Q9BRP4-2]
F5H0C4
ENST00000544552.5 [Q9BRP4-2]
ENST00000376384.9 [Q9BRP4-2]
F5H3E9
ENST00000544909.5
ENST00000540659.1