P3H3 | OmnibusX

Name	Number of supported studies	Average coverage
retinal cone cell	4 studies	38% ± 19%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of P3H3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3403.50	244 / 245	91%	19.66	459 / 502
thymus	100%	2070.97	652 / 653	91%	38.54	550 / 605
pancreas	93%	792.58	305 / 328	97%	35.41	173 / 178
breast	96%	1773.96	442 / 459	91%	30.04	1016 / 1118
lung	99%	1584.26	574 / 578	84%	20.43	970 / 1155
bladder	100%	3145.33	21 / 21	79%	21.23	399 / 504
adrenal gland	95%	1218.14	245 / 258	82%	62.62	189 / 230
skin	99%	2404.18	1787 / 1809	75%	23.71	355 / 472
uterus	100%	5646.88	170 / 170	71%	32.19	327 / 459
stomach	98%	1347.32	353 / 359	71%	10.84	203 / 286
ovary	100%	4766.41	180 / 180	69%	13.78	298 / 430
intestine	93%	1746.05	903 / 966	70%	12.88	369 / 527
brain	80%	1521.50	2124 / 2642	80%	11.77	564 / 705
esophagus	85%	1513.00	1233 / 1445	58%	9.34	107 / 183
kidney	90%	983.47	80 / 89	48%	9.98	436 / 901
blood vessel	100%	3493.63	1333 / 1335	0%	0	0 / 0
heart	97%	1610.79	837 / 861	0%	0	0 / 0
adipose	96%	1458.00	1156 / 1204	0%	0	0 / 0
spleen	76%	572.37	183 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	70%	11.25	56 / 80
tonsil	0%	0	0 / 0	53%	10.06	24 / 45
lymph node	0%	0	0 / 0	38%	3.55	11 / 29
liver	6%	43.39	13 / 226	16%	2.89	64 / 406
muscle	8%	50.09	61 / 803	0%	0	0 / 0
peripheral blood	0%	0.78	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0017185	Biological process	peptidyl-lysine hydroxylation
GO_0032964	Biological process	collagen biosynthetic process
GO_0032963	Biological process	collagen metabolic process
GO_0005783	Cellular component	endoplasmic reticulum
GO_1902494	Cellular component	catalytic complex
GO_0005506	Molecular function	iron ion binding
GO_0031418	Molecular function	L-ascorbic acid binding
GO_0019797	Molecular function	procollagen-proline 3-dioxygenase activity

Gene name	P3H3
Protein name	Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)
Synonyms	LEPREL2
Description	FUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. .
Accessions	Q8IVL6 ENST00000290510.10 [Q8IVL6-1]

P3H3 report