I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 36% ± 5% | |
| glutamatergic neuron | 3 studies | 48% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 36% ± 5% | |
| glutamatergic neuron | 3 studies | 48% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 32% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1485.98 | 1444 / 1445 | 99% | 8.80 | 182 / 183 |
| thymus | 100% | 1377.62 | 652 / 653 | 98% | 7.64 | 593 / 605 |
| brain | 99% | 1670.50 | 2607 / 2642 | 99% | 7.25 | 699 / 705 |
| prostate | 100% | 2026.10 | 245 / 245 | 98% | 7.27 | 491 / 502 |
| pancreas | 100% | 831.99 | 327 / 328 | 98% | 5.89 | 174 / 178 |
| breast | 100% | 1484.31 | 459 / 459 | 97% | 7.27 | 1088 / 1118 |
| uterus | 100% | 2694.86 | 170 / 170 | 97% | 8.91 | 444 / 459 |
| intestine | 100% | 1933.27 | 966 / 966 | 96% | 7.27 | 505 / 527 |
| stomach | 100% | 1247.17 | 359 / 359 | 95% | 7.00 | 273 / 286 |
| lung | 100% | 1644.61 | 577 / 578 | 95% | 7.45 | 1094 / 1155 |
| bladder | 100% | 1449.67 | 21 / 21 | 94% | 6.67 | 475 / 504 |
| skin | 100% | 1485.18 | 1809 / 1809 | 93% | 7.37 | 437 / 472 |
| adrenal gland | 100% | 1682.51 | 258 / 258 | 92% | 5.34 | 211 / 230 |
| kidney | 100% | 1243.70 | 89 / 89 | 92% | 7.44 | 826 / 901 |
| ovary | 100% | 2073.61 | 180 / 180 | 76% | 3.54 | 327 / 430 |
| liver | 96% | 513.48 | 216 / 226 | 26% | 0.98 | 107 / 406 |
| spleen | 100% | 1544.62 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.82 | 1 / 1 |
| adipose | 100% | 1103.31 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 853.10 | 801 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 1063.69 | 1321 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 695.87 | 834 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 5.69 | 42 / 45 |
| eye | 0% | 0 | 0 / 0 | 79% | 5.41 | 63 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 3.65 | 22 / 29 |
| peripheral blood | 46% | 461.38 | 427 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031669 | Biological process | cellular response to nutrient levels |
| GO_0071108 | Biological process | protein K48-linked deubiquitination |
| GO_0035871 | Biological process | protein K11-linked deubiquitination |
| GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0050821 | Biological process | protein stabilization |
| GO_1990167 | Biological process | protein K27-linked deubiquitination |
| GO_0006508 | Biological process | proteolysis |
| GO_0044313 | Biological process | protein K6-linked deubiquitination |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
| Gene name | OTUD3 |
| Protein name | OTU domain-containing protein 3 (EC 3.4.19.12) OTUD3 protein |
| Synonyms | KIAA0459 |
| Description | FUNCTION: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains . Important regulator of energy metabolism . Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation . In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation . Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination . . |
| Accessions | Q5T2D3 ENST00000375120.4 Q0VDK5 |
