OTUB2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OTUB2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OTUB2 at tissue level.

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0035871Biological processprotein K11-linked deubiquitination
GO_2000780Biological processnegative regulation of double-strand break repair
GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameOTUB2
Protein nameUbiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)
OTU domain, ubiquitin aldehyde binding 2, isoform CRA_b
OTUB2 protein
SynonymsOTB2
OTU2
hCG_22343
pp9457
C14orf137
DescriptionFUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. .

AccessionsENST00000553723.1 [Q96DC9-2]
ENST00000617748.3 [Q96DC9-1]
Q8WYS4
ENST00000203664.10 [Q96DC9-1]
ENST00000628711.1 [Q96DC9-2]
Q96DC9
Q9BWI9