OTOP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OTOP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OTOP1 at tissue level.

III. Associated gene sets

GO_0042472Biological processinner ear morphogenesis
GO_0009590Biological processdetection of gravity
GO_0060336Biological processnegative regulation of type II interferon-mediated signaling pathway
GO_0031214Biological processbiomineral tissue development
GO_0032869Biological processcellular response to insulin stimulus
GO_1902600Biological processproton transmembrane transport
GO_0005902Cellular componentmicrovillus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0015252Molecular functionproton channel activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameOTOP1
Protein nameProton channel OTOP1 (Otopetrin-1) (hOtop1)
Synonyms
DescriptionFUNCTION: Proton-selective channel that specifically transports protons into cells . Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes . In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity). .

AccessionsQ7RTM1
ENST00000296358.5