OTC report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OTC at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OTC at tissue level.

III. Associated gene sets

GO_0006593Biological processornithine catabolic process
GO_0007494Biological processmidgut development
GO_0032868Biological processresponse to insulin
GO_0001889Biological processliver development
GO_0055081Biological processmonoatomic anion homeostasis
GO_0097272Biological processammonium homeostasis
GO_0070781Biological processresponse to biotin
GO_0000050Biological processurea cycle
GO_0010043Biological processresponse to zinc ion
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0042450Biological processarginine biosynthetic process via ornithine
GO_0019240Biological processcitrulline biosynthetic process
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0004585Molecular functionornithine carbamoyltransferase activity
GO_0005543Molecular functionphospholipid binding
GO_0042802Molecular functionidentical protein binding
GO_0016597Molecular functionamino acid binding
GO_0042301Molecular functionphosphate ion binding

IV. Literature review

[source]
Gene nameOTC
Protein nameornithine carbamoyltransferase (EC 2.1.3.3)
Ornithine transcarbamylase, mitochondrial (OTCase) (EC 2.1.3.3) (Ornithine carbamoyltransferase, mitochondrial)
Synonyms
DescriptionFUNCTION: Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline . The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion . .

AccessionsENST00000643344.1
ENST00000039007.5
P00480
A0A2R8Y829