OAZ3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OAZ3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OAZ3 at tissue level.

III. Associated gene sets

GO_0045732Biological processpositive regulation of protein catabolic process
GO_1902268Biological processnegative regulation of polyamine transmembrane transport
GO_0007283Biological processspermatogenesis
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0006596Biological processpolyamine biosynthetic process
GO_0072562Cellular componentblood microparticle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008073Molecular functionornithine decarboxylase inhibitor activity

IV. Literature review

[source]
Gene nameOAZ3
Protein nameOrnithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3)
Ornithine decarboxylase antizyme 3
Synonyms
DescriptionFUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity . Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). .

AccessionsENST00000635374.1
A0A0G2JH29
A0A0U1RR57
Q5SZR7
ENST00000400999
H0Y7Y4
A8MW57
ENST00000453029.2
A0A0U1RRA2
ENST00000321531.10
ENST00000582415.2
J3QLT2
ENST00000479764.7
ENST00000400999.7 [Q9UMX2-1]
ENST00000635322.1
Q9UMX2