NUDT4B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NUDT4B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NUDT4B at tissue level.

III. Associated gene sets

GO_0071543Biological processdiphosphoinositol polyphosphate metabolic process
GO_1901909Biological processdiadenosine hexaphosphate catabolic process
GO_1901911Biological processadenosine 5'-(hexahydrogen pentaphosphate) catabolic process
GO_1901907Biological processdiadenosine pentaphosphate catabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0034432Molecular functionbis(5'-adenosyl)-pentaphosphatase activity
GO_0000298Molecular functionendopolyphosphatase activity
GO_0008486Molecular functiondiphosphoinositol-polyphosphate diphosphatase activity
GO_0034431Molecular functionbis(5'-adenosyl)-hexaphosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNUDT4B
Protein nameDiphosphoinositol polyphosphate phosphohydrolase NUDT4B (DIPP-2B) (EC 3.6.1.52) (Nucleoside diphosphate-linked moiety X motif 4B) (Nudix motif 4B) (Nudix hydrolase 4B)
Synonyms
DescriptionFUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. .

AccessionsA0A024RBG1
ENST00000322209.5