NUDT18 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NUDT18 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NUDT18 at tissue level.

III. Associated gene sets

GO_0046057Biological processdADP catabolic process
GO_0046712Biological processGDP catabolic process
GO_0046067Biological processdGDP catabolic process
GO_0055086Biological processnucleobase-containing small molecule metabolic process
GO_0005829Cellular componentcytosol
GO_0044716Molecular function8-oxo-GDP phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0044715Molecular function8-oxo-dGDP phosphatase activity
GO_0044717Molecular function8-hydroxy-dADP phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUDT18
Protein nameNudix hydrolase 18
8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)
SynonymsMTH3
DescriptionFUNCTION: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. .

AccessionsQ6ZVK8
A0A087WW30
ENST00000611621.2 [Q6ZVK8-1]
ENST00000613958.1