NUAK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000772Biological processregulation of cellular senescence
GO_0006974Biological processDNA damage response
GO_0035507Biological processregulation of myosin-light-chain-phosphatase activity
GO_0007155Biological processcell adhesion
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0006468Biological processprotein phosphorylation
GO_0030155Biological processregulation of cell adhesion
GO_0042127Biological processregulation of cell population proliferation
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUAK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
NUAK family kinase 1
SynonymsKIAA0537
ARK5
OMPHK1
DescriptionFUNCTION: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair . .

AccessionsO60285
F8VZ96
F8VSH4
ENST00000548902.1
ENST00000553094.1
ENST00000261402.7 [O60285-1]
ENST00000549704.1
F8VXF0