Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 30% ± 12% | |
vein endothelial cell | 12 studies | 29% ± 12% | |
oligodendrocyte | 10 studies | 26% ± 7% | |
endothelial cell of artery | 9 studies | 23% ± 4% | |
glutamatergic neuron | 9 studies | 53% ± 22% | |
microglial cell | 9 studies | 31% ± 10% | |
endothelial cell of vascular tree | 8 studies | 23% ± 8% | |
GABAergic neuron | 6 studies | 35% ± 17% | |
capillary endothelial cell | 5 studies | 22% ± 3% | |
interneuron | 5 studies | 34% ± 21% | |
neuron | 4 studies | 36% ± 13% | |
granule cell | 4 studies | 19% ± 1% | |
cardiac muscle cell | 4 studies | 26% ± 4% | |
fibroblast | 3 studies | 21% ± 2% | |
smooth muscle cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 11 studies | 36% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 97% | 3871.65 | 2559 / 2642 | 99% | 19.81 | 695 / 705 |
breast | 100% | 4227.33 | 458 / 459 | 96% | 16.06 | 1068 / 1118 |
lung | 96% | 3292.90 | 555 / 578 | 95% | 17.96 | 1098 / 1155 |
prostate | 96% | 2070.11 | 234 / 245 | 84% | 8.48 | 424 / 502 |
uterus | 100% | 4058.35 | 170 / 170 | 80% | 12.20 | 366 / 459 |
bladder | 100% | 1615.90 | 21 / 21 | 75% | 9.43 | 378 / 504 |
ovary | 99% | 1973.54 | 178 / 180 | 75% | 8.39 | 322 / 430 |
adrenal gland | 91% | 1192.17 | 234 / 258 | 83% | 9.01 | 190 / 230 |
thymus | 90% | 1550.63 | 590 / 653 | 76% | 5.58 | 460 / 605 |
esophagus | 77% | 1318.91 | 1107 / 1445 | 90% | 13.55 | 164 / 183 |
intestine | 90% | 1375.97 | 865 / 966 | 72% | 6.37 | 377 / 527 |
kidney | 73% | 1135.60 | 65 / 89 | 81% | 10.58 | 726 / 901 |
stomach | 74% | 975.02 | 266 / 359 | 79% | 7.44 | 227 / 286 |
pancreas | 47% | 416.47 | 153 / 328 | 97% | 17.58 | 173 / 178 |
skin | 97% | 3715.81 | 1754 / 1809 | 46% | 3.72 | 218 / 472 |
liver | 46% | 437.24 | 105 / 226 | 81% | 7.65 | 328 / 406 |
adipose | 100% | 5268.92 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 3950.06 | 803 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 3503.60 | 1328 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 3188.76 | 842 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 80% | 11.87 | 36 / 45 |
lymph node | 0% | 0 | 0 / 0 | 21% | 0.91 | 6 / 29 |
eye | 0% | 0 | 0 / 0 | 8% | 0.34 | 6 / 80 |
spleen | 2% | 16.96 | 5 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 1% | 7.34 | 7 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_2000772 | Biological process | regulation of cellular senescence |
GO_0006974 | Biological process | DNA damage response |
GO_0035507 | Biological process | regulation of myosin-light-chain-phosphatase activity |
GO_0007155 | Biological process | cell adhesion |
GO_1901796 | Biological process | regulation of signal transduction by p53 class mediator |
GO_0006468 | Biological process | protein phosphorylation |
GO_0030155 | Biological process | regulation of cell adhesion |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0005654 | Cellular component | nucleoplasm |
GO_0001650 | Cellular component | fibrillar center |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0002039 | Molecular function | p53 binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NUAK1 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) NUAK family kinase 1 |
Synonyms | KIAA0537 ARK5 OMPHK1 |
Description | FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair . . |
Accessions | O60285 F8VZ96 F8VSH4 ENST00000548902.1 ENST00000553094.1 ENST00000261402.7 [O60285-1] ENST00000549704.1 F8VXF0 |