NTMT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NTMT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NTMT2 at tissue level.

III. Associated gene sets

GO_0006480Biological processN-terminal protein amino acid methylation
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0071885Molecular functionN-terminal protein N-methyltransferase activity

IV. Literature review

[source]
Gene nameNTMT2
Protein nameN-terminal Xaa-Pro-Lys N-methyltransferase 2 (EC 2.1.1.299) (Alpha N-terminal protein methyltransferase 1B) (Methyltransferase-like protein 11B) (X-Pro-Lys N-terminal protein methyltransferase 1B) (NTM1B)
SynonymsNRMT2
C1orf184
METTL11B
DescriptionFUNCTION: Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif . Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) . May activate NTMT1 by priming its substrates for trimethylation . .

AccessionsQ5VVY1
ENST00000439373.3