NSUN6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001510Biological processRNA methylation
GO_0006400Biological processtRNA modification
GO_0030488Biological processtRNA methylation
GO_0002946Biological processtRNA C5-cytosine methylation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000049Molecular functiontRNA binding
GO_0016428Molecular functiontRNA (cytidine-5-)-methyltransferase activity

IV. Literature review

[source]
Gene nameNSUN6
Protein nametRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun and PUA domain-containing protein 1) (NOL1/NOP2/Sun domain family member 6)
NOP2/Sun RNA methyltransferase 6
SynonymsNOPD1
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) . In vitro also methylates tRNA(Thr)(AGT) . Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates . .

AccessionsQ8TEA1
ENST00000607346.1
ENST00000606425.2
ENST00000377304.7
U3KQU2
A0A0D9SF14