Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 19 studies | 24% ± 9% | |
| astrocyte | 11 studies | 34% ± 22% | |
| glutamatergic neuron | 8 studies | 44% ± 28% | |
| oligodendrocyte precursor cell | 8 studies | 25% ± 9% | |
| GABAergic neuron | 7 studies | 45% ± 24% | |
| oligodendrocyte | 7 studies | 32% ± 22% | |
| interneuron | 6 studies | 42% ± 27% | |
| adipocyte | 6 studies | 24% ± 7% | |
| fibroblast | 6 studies | 23% ± 5% | |
| neuron | 5 studies | 23% ± 9% | |
| microglial cell | 5 studies | 31% ± 25% | |
| ciliated cell | 5 studies | 20% ± 4% | |
| hepatocyte | 4 studies | 65% ± 25% | |
| epithelial cell | 4 studies | 33% ± 12% | |
| cardiac muscle cell | 4 studies | 18% ± 2% | |
| lymphocyte | 4 studies | 21% ± 3% | |
| mast cell | 4 studies | 21% ± 4% | |
| hematopoietic precursor cell | 3 studies | 17% ± 2% | |
| GABAergic interneuron | 3 studies | 20% ± 3% | |
| endothelial cell of vascular tree | 3 studies | 23% ± 9% | |
| macrophage | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1039.19 | 21 / 21 | 100% | 13.33 | 504 / 504 |
| liver | 100% | 2371.63 | 226 / 226 | 100% | 16.86 | 406 / 406 |
| prostate | 100% | 1280.33 | 245 / 245 | 100% | 13.54 | 502 / 502 |
| breast | 100% | 898.54 | 459 / 459 | 100% | 12.38 | 1117 / 1118 |
| brain | 100% | 1017.90 | 2636 / 2642 | 100% | 15.73 | 705 / 705 |
| thymus | 100% | 1498.41 | 653 / 653 | 100% | 11.01 | 603 / 605 |
| uterus | 100% | 966.72 | 170 / 170 | 100% | 10.96 | 457 / 459 |
| ovary | 100% | 1415.90 | 180 / 180 | 100% | 7.92 | 428 / 430 |
| intestine | 100% | 715.97 | 966 / 966 | 99% | 9.08 | 524 / 527 |
| lung | 100% | 772.38 | 576 / 578 | 100% | 8.67 | 1151 / 1155 |
| adrenal gland | 100% | 1281.56 | 258 / 258 | 99% | 12.53 | 228 / 230 |
| esophagus | 100% | 586.55 | 1445 / 1445 | 99% | 7.78 | 181 / 183 |
| stomach | 100% | 678.40 | 359 / 359 | 99% | 8.37 | 282 / 286 |
| pancreas | 100% | 765.32 | 327 / 328 | 99% | 9.33 | 176 / 178 |
| kidney | 100% | 872.30 | 89 / 89 | 98% | 8.23 | 886 / 901 |
| skin | 100% | 715.78 | 1805 / 1809 | 93% | 6.75 | 438 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.32 | 29 / 29 |
| spleen | 100% | 1120.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 9.06 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.55 | 1 / 1 |
| adipose | 100% | 729.38 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 513.55 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 592.05 | 840 / 861 | 0% | 0 | 0 / 0 |
| muscle | 90% | 284.49 | 726 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 73% | 3.99 | 58 / 80 |
| peripheral blood | 53% | 346.59 | 493 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001510 | Biological process | RNA methylation |
| GO_0006400 | Biological process | tRNA modification |
| GO_0030488 | Biological process | tRNA methylation |
| GO_0002946 | Biological process | tRNA C5-cytosine methylation |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0016428 | Molecular function | tRNA (cytidine-5-)-methyltransferase activity |
| Gene name | NSUN6 |
| Protein name | tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun and PUA domain-containing protein 1) (NOL1/NOP2/Sun domain family member 6) NOP2/Sun RNA methyltransferase 6 |
| Synonyms | NOPD1 |
| Description | FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) . In vitro also methylates tRNA(Thr)(AGT) . Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates . . |
| Accessions | Q8TEA1 ENST00000607346.1 ENST00000606425.2 ENST00000377304.7 U3KQU2 A0A0D9SF14 |