NSUN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010793Biological processregulation of mRNA export from nucleus
GO_0006397Biological processmRNA processing
GO_0048820Biological processhair follicle maturation
GO_0001701Biological processin utero embryonic development
GO_2000736Biological processregulation of stem cell differentiation
GO_0036416Biological processtRNA stabilization
GO_0051301Biological processcell division
GO_0033313Biological processmeiotic cell cycle checkpoint signaling
GO_0006400Biological processtRNA modification
GO_0030488Biological processtRNA methylation
GO_0007286Biological processspermatid development
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0033391Cellular componentchromatoid body
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0062152Molecular functionmRNA (cytidine-5-)-methyltransferase activity
GO_0016428Molecular functiontRNA (cytidine-5-)-methyltransferase activity
GO_0003723Molecular functionRNA binding
GO_0000049Molecular functiontRNA binding

IV. Literature review

[source]
Gene nameNSUN2
Protein nameRNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)
NOP2/Sun RNA methyltransferase 2
SynonymsSAKI
TRM4
DescriptionFUNCTION: RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) . Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay . Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors . tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) . Also mediates C(5)-methylation of mitochondrial tRNAs . Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts . Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling . Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs . Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation . May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity . .

AccessionsQ08J23
A0A140T9Y7
ENST00000264670.11 [Q08J23-1]
ENST00000506139.5 [Q08J23-2]
ENST00000504374.5
ENST00000514127.1
A0A140T9Z1