NRDE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0031048Biological processregulatory ncRNA-mediated heterochromatin formation
GO_1902369Biological processnegative regulation of RNA catabolic process
GO_0046833Biological processpositive regulation of RNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0051301Biological processcell division
GO_0006397Biological processmRNA processing
GO_0000278Biological processmitotic cell cycle
GO_0048255Biological processmRNA stabilization
GO_0016607Cellular componentnuclear speck
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameNRDE2
Protein nameNRDE-2, necessary for RNA interference, domain containing
Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog)
SynonymsC14orf102
DescriptionFUNCTION: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation . Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation . Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome . By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm . U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis . Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites . Plays a role in DNA damage response . .

AccessionsENST00000628832.1
ENST00000556189.5
ENST00000553409.5
Q9H7Z3
ENST00000354366.8
G3V338
H0YJT0
H0YJT6
ENST00000554464.1