I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 45% ± 22% | |
| adipocyte | 3 studies | 42% ± 6% | |
| GABAergic neuron | 3 studies | 22% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 45% ± 22% | |
| adipocyte | 3 studies | 42% ± 6% | |
| GABAergic neuron | 3 studies | 22% ± 3% |
Insufficient scRNA-seq data for expression of NPY1R at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 99% | 3113.34 | 88 / 89 | 87% | 17.20 | 786 / 901 |
| breast | 92% | 3003.36 | 424 / 459 | 80% | 254.92 | 893 / 1118 |
| adrenal gland | 99% | 3576.90 | 256 / 258 | 70% | 6.03 | 160 / 230 |
| thymus | 88% | 1156.95 | 577 / 653 | 77% | 6.92 | 467 / 605 |
| pancreas | 88% | 1061.79 | 288 / 328 | 58% | 3.75 | 104 / 178 |
| uterus | 89% | 1054.12 | 151 / 170 | 17% | 2.37 | 80 / 459 |
| spleen | 100% | 12549.11 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 97% | 2658.22 | 1173 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 97% | 3818.77 | 1291 / 1335 | 0% | 0 | 0 / 0 |
| brain | 61% | 680.46 | 1621 / 2642 | 33% | 1.83 | 231 / 705 |
| skin | 69% | 846.26 | 1242 / 1809 | 14% | 1.83 | 68 / 472 |
| liver | 58% | 338.06 | 132 / 226 | 24% | 2.94 | 98 / 406 |
| prostate | 43% | 268.58 | 106 / 245 | 28% | 0.86 | 139 / 502 |
| intestine | 30% | 212.40 | 293 / 966 | 20% | 1.31 | 103 / 527 |
| bladder | 24% | 103.76 | 5 / 21 | 20% | 2.22 | 99 / 504 |
| lung | 32% | 185.58 | 186 / 578 | 11% | 0.96 | 130 / 1155 |
| ovary | 24% | 294.91 | 44 / 180 | 14% | 1.69 | 61 / 430 |
| esophagus | 30% | 196.12 | 434 / 1445 | 8% | 0.55 | 15 / 183 |
| heart | 33% | 202.40 | 287 / 861 | 0% | 0 | 0 / 0 |
| stomach | 18% | 108.31 | 66 / 359 | 12% | 1.26 | 34 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 0.79 | 7 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.18 | 3 / 45 |
| muscle | 4% | 23.17 | 35 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019233 | Biological process | sensory perception of pain |
| GO_0007631 | Biological process | feeding behavior |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0007218 | Biological process | neuropeptide signaling pathway |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0040014 | Biological process | regulation of multicellular organism growth |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043005 | Cellular component | neuron projection |
| GO_0001601 | Molecular function | peptide YY receptor activity |
| GO_0042923 | Molecular function | neuropeptide binding |
| GO_0008188 | Molecular function | neuropeptide receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0001602 | Molecular function | pancreatic polypeptide receptor activity |
| GO_0004983 | Molecular function | neuropeptide Y receptor activity |
| Gene name | NPY1R |
| Protein name | Neuropeptide Y receptor type 1 (NPY1-R) Neuropeptide Y receptor type 1 Neuropeptide Y receptor Y1 |
| Synonyms | NPYY1 NPYR |
| Description | FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. |
| Accessions | D6RI97 ENST00000511901.1 D6REY0 ENST00000515701.1 ENST00000504391.5 ENST00000504790.1 ENST00000509586.5 D6RC44 P25929 ENST00000296533.3 D6R9D0 D6RHH6 B4DKL9 ENST00000512819.1 |
