NOXO1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOXO1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOXO1 at tissue level.

III. Associated gene sets

GO_0022617Biological processextracellular matrix disassembly
GO_0042554Biological processsuperoxide anion generation
GO_0060263Biological processregulation of respiratory burst
GO_0010310Biological processregulation of hydrogen peroxide metabolic process
GO_0043020Cellular componentNADPH oxidase complex
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0016176Molecular functionsuperoxide-generating NADPH oxidase activator activity
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene nameNOXO1
Protein nameNADPH oxidase organizer 1
NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)
SynonymsP41NOX
SH3PXD5
DescriptionFUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. .

AccessionsENST00000709273.1 [Q8NFA2-1]
ENST00000566005.5 [Q8NFA2-2]
ENST00000397280.8 [Q8NFA2-1]
ENST00000567471.1
ENST00000354249.8 [Q8NFA2-4]
ENST00000709274.1 [Q8NFA2-2]
ENST00000709272.1 [Q8NFA2-4]
ENST00000709271.1 [Q8NFA2-3]
Q8NFA2
ENST00000356120.9 [Q8NFA2-3]
H3BN18