NOTCH2NLC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOTCH2NLC at tissue level.

III. Associated gene sets

GO_0021987Biological processcerebral cortex development
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0007219Biological processNotch signaling pathway
GO_0005576Cellular componentextracellular region
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNOTCH2NLC
Protein nameNotch homolog 2 N-terminal-like protein C
Synonyms
DescriptionFUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway . Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production . Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect . Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 . Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity). .

AccessionsP0DPK4
ENST00000578189.1 [P0DPK4-2]
ENST00000652191.1 [P0DPK4-2]
ENST00000650865.2 [P0DPK4-1]