NOTCH2NLB report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOTCH2NLB at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOTCH2NLB at tissue level.

III. Associated gene sets

GO_0021987Biological processcerebral cortex development
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0007219Biological processNotch signaling pathway
GO_0005576Cellular componentextracellular region
GO_0005112Molecular functionNotch binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNOTCH2NLB
Protein nameNotch homolog 2 N-terminal-like protein B
Synonyms
DescriptionFUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway . Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production . Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect . Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 . Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation . .

AccessionsP0DPK3
ENST00000593495.4 [P0DPK3-2]