NMRK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NMRK2 at tissue level.

III. Associated gene sets

GO_0009435Biological processNAD biosynthetic process
GO_0019674Biological processNAD metabolic process
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0050262Molecular functionribosylnicotinamide kinase activity
GO_0061769Molecular functionribosylnicotinate kinase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNMRK2
Protein nameNicotinamide riboside kinase 2
Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2)
SynonymsITGB1BP3
NRK2
DescriptionFUNCTION: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. .

AccessionsM0QX67
ENST00000597889.1
M0R0T8
ENST00000616156.4 [Q9NPI5-3]
ENST00000168977.7 [Q9NPI5-1]
ENST00000593949.1 [Q9NPI5-3]
Q9NPI5
ENST00000599576.5