NME8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NME8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NME8 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007283Biological processspermatogenesis
GO_0030317Biological processflagellated sperm motility
GO_0034614Biological processcellular response to reactive oxygen species
GO_0030154Biological processcell differentiation
GO_0005930Cellular componentaxoneme
GO_0016607Cellular componentnuclear speck
GO_0097225Cellular componentsperm midpiece
GO_0097228Cellular componentsperm principal piece
GO_0005737Cellular componentcytoplasm
GO_0005829Cellular componentcytosol
GO_0036157Cellular componentouter dynein arm
GO_0097598Cellular componentsperm cytoplasmic droplet
GO_0005634Cellular componentnucleus
GO_0008017Molecular functionmicrotubule binding
GO_0008408Molecular function3'-5' exonuclease activity

IV. Literature review

[source]
Gene nameNME8
Protein nameThioredoxin domain-containing protein 3 (3'-5' exonuclease NME8) (EC 3.1.-.-) (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2)
NME/NM23 family member 8
SynonymsSPTRX2
TXNDC3
DescriptionFUNCTION: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds . Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair . .

AccessionsQ8N427
ENST00000444718.5
F8WEA2
C9JG62
ENST00000426106.1
C9JIT0
ENST00000440017.5
ENST00000455500.5
ENST00000199447.9