NLRP5 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	56%	17.09	257 / 459	15%	1.11	171 / 1118
ovary	34%	90.46	62 / 180	1%	0.01	4 / 430
prostate	29%	2.13	70 / 245	0%	0.00	1 / 502
muscle	25%	0.79	202 / 803	0%	0	0 / 0
pancreas	21%	1.01	69 / 328	1%	0.07	1 / 178
bladder	14%	0.52	3 / 21	1%	0.03	3 / 504
heart	14%	0.49	123 / 861	0%	0	0 / 0
uterus	13%	0.39	22 / 170	1%	0.27	6 / 459
stomach	10%	0.30	37 / 359	3%	0.05	8 / 286
peripheral blood	12%	0.40	112 / 929	0%	0	0 / 0
esophagus	10%	0.34	151 / 1445	1%	0.08	2 / 183
adrenal gland	11%	0.28	28 / 258	0%	0.09	1 / 230
thymus	11%	5.16	69 / 653	0%	0	0 / 605
intestine	9%	0.27	91 / 966	1%	0.02	5 / 527
lung	8%	0.22	46 / 578	2%	0.12	23 / 1155
adipose	10%	0.25	118 / 1204	0%	0	0 / 0
blood vessel	10%	0.24	127 / 1335	0%	0	0 / 0
brain	9%	0.29	245 / 2642	0%	0	0 / 705
skin	9%	0.25	161 / 1809	0%	0.00	1 / 472
spleen	8%	0.26	20 / 241	0%	0	0 / 0
liver	5%	0.12	12 / 226	0%	0.01	1 / 406
kidney	4%	0.12	4 / 89	1%	0.01	6 / 901
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0032879	Biological process	regulation of localization
GO_0050727	Biological process	regulation of inflammatory response
GO_0060471	Biological process	cortical granule exocytosis
GO_0051293	Biological process	establishment of spindle localization
GO_0051302	Biological process	regulation of cell division
GO_0040019	Biological process	positive regulation of embryonic development
GO_0006887	Biological process	exocytosis
GO_0007015	Biological process	actin filament organization
GO_0051656	Biological process	establishment of organelle localization
GO_0005730	Cellular component	nucleolus
GO_0005739	Cellular component	mitochondrion
GO_0106333	Cellular component	subcortical maternal complex
GO_0005794	Cellular component	Golgi apparatus
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0060473	Cellular component	cortical granule
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005634	Cellular component	nucleus
GO_0015631	Molecular function	tubulin binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	NLRP5
Protein name	NLR family pyrin domain containing 5 NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require)
Synonyms	NALP5 MATER
Description	FUNCTION: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity). .
Accessions	P59047 ENST00000390649.8 M0R0W4 ENST00000597673.1

NLRP5 report