NFS1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NFS1 at tissue level.

III. Associated gene sets

GO_0018283Biological processiron incorporation into metallo-sulfur cluster
GO_0006777Biological processMo-molybdopterin cofactor biosynthetic process
GO_0044572Biological process[4Fe-4S] cluster assembly
GO_0016226Biological processiron-sulfur cluster assembly
GO_0044571Biological process[2Fe-2S] cluster assembly
GO_0099128Cellular componentmitochondrial [2Fe-2S] assembly complex
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_1990229Cellular componentiron-sulfur cluster assembly complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0051536Molecular functioniron-sulfur cluster binding
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0031071Molecular functioncysteine desulfurase activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFS1
Protein nameNFS1 cysteine desulfurase
Cysteine desulfurase (EC 2.8.1.7)
cysteine desulfurase (EC 2.8.1.7)
NFS1 cysteine desulfurase (NFS1 nitrogen fixation 1 homolog (S. cerevisiae))
SynonymshCG_38220
HUSSY-08
NIFS
DescriptionFUNCTION: [Isoform Mitochondrial]: Cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex, leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU . The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 . After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). .; FUNCTION: [Isoform Cytoplasmic]: May catalyze the desulfuration of L-cysteine to L-alanine as component of the cysteine desulfurase complex (NFS1:LYRM4), leading to the formation of a cysteine persulfide intermediate . Acts as a sulfur donor for MOCS3 by transferring the sulfur of the cysteine persulfide intermediate on MOCS3 . .

AccessionsENST00000397425.5 [Q9Y697-2]
ENST00000374092.9 [Q9Y697-1]
Q8WV90
F8WER8
ENST00000456462.5
F2Z2E7
Q9Y697
ENST00000306750.3
F8WB23
ENST00000541387.5 [Q9Y697-3]
A2A2M1
ENST00000413203.5
ENST00000419569.5
ENST00000440385.5
Q5QP19
ENST00000374085.5 [Q9Y697-2]