NEUROD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NEUROD2 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0061564Biological processaxon development
GO_0031915Biological processpositive regulation of synaptic plasticity
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_2000297Biological processnegative regulation of synapse maturation
GO_0021695Biological processcerebellar cortex development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0008306Biological processassociative learning
GO_0071277Biological processcellular response to calcium ion
GO_0071257Biological processcellular response to electrical stimulus
GO_0001662Biological processbehavioral fear response
GO_0090129Biological processpositive regulation of synapse maturation
GO_0007399Biological processnervous system development
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0007423Biological processsensory organ development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070888Molecular functionE-box binding

IV. Literature review

[source]
Gene nameNEUROD2
Protein nameNeurogenic differentiation factor 2 (NeuroD2) (Class A basic helix-loop-helix protein 1) (bHLHa1) (NeuroD-related factor) (NDRF)
SynonymsBHLHA1
NDRF
DescriptionFUNCTION: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). .

AccessionsENST00000302584.5
Q15784