I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 5 studies | 34% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 5 studies | 34% ± 10% |
Insufficient scRNA-seq data for expression of NEU4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 730.28 | 2636 / 2642 | 96% | 50.81 | 677 / 705 |
| liver | 100% | 3645.00 | 226 / 226 | 67% | 16.60 | 274 / 406 |
| intestine | 51% | 826.88 | 493 / 966 | 60% | 5.72 | 318 / 527 |
| kidney | 60% | 109.00 | 53 / 89 | 6% | 0.47 | 52 / 901 |
| muscle | 50% | 408.44 | 401 / 803 | 0% | 0 | 0 / 0 |
| ovary | 6% | 5.66 | 10 / 180 | 37% | 1.76 | 161 / 430 |
| stomach | 1% | 1.11 | 4 / 359 | 41% | 3.24 | 118 / 286 |
| adipose | 28% | 45.99 | 337 / 1204 | 0% | 0 | 0 / 0 |
| lung | 15% | 21.78 | 89 / 578 | 5% | 0.27 | 56 / 1155 |
| esophagus | 1% | 2.57 | 15 / 1445 | 19% | 1.34 | 34 / 183 |
| bladder | 0% | 0 | 0 / 21 | 17% | 1.63 | 88 / 504 |
| uterus | 4% | 6.55 | 7 / 170 | 10% | 0.83 | 46 / 459 |
| prostate | 13% | 14.60 | 31 / 245 | 1% | 0.02 | 3 / 502 |
| breast | 5% | 7.36 | 24 / 459 | 7% | 0.52 | 80 / 1118 |
| thymus | 8% | 9.35 | 52 / 653 | 2% | 0.09 | 14 / 605 |
| adrenal gland | 4% | 8.00 | 10 / 258 | 6% | 0.44 | 14 / 230 |
| peripheral blood | 8% | 12.10 | 77 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 8% | 0.50 | 14 / 178 |
| spleen | 6% | 13.47 | 15 / 241 | 0% | 0 | 0 / 0 |
| skin | 0% | 0.70 | 8 / 1809 | 2% | 0.20 | 10 / 472 |
| heart | 3% | 2.75 | 22 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 1.27 | 14 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010977 | Biological process | negative regulation of neuron projection development |
| GO_0009313 | Biological process | oligosaccharide catabolic process |
| GO_0006516 | Biological process | glycoprotein catabolic process |
| GO_0006689 | Biological process | ganglioside catabolic process |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0019866 | Cellular component | organelle inner membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0052795 | Molecular function | exo-alpha-(2->6)-sialidase activity |
| GO_0052796 | Molecular function | exo-alpha-(2->8)-sialidase activity |
| GO_0052794 | Molecular function | exo-alpha-(2->3)-sialidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004308 | Molecular function | exo-alpha-sialidase activity |
| Gene name | NEU4 |
| Protein name | Neuraminidase 4 (Sialidase-4) Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4) exo-alpha-sialidase (EC 3.2.1.18) |
| Synonyms | LP5125 hCG_31619 |
| Description | FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 . Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation . Has sialidase activity toward mucin, fetuin and sialyllactose . . |
| Accessions | ENST00000404257.5 [Q8WWR8-2] ENST00000630923.2 [Q8WWR8-1] ENST00000625452.2 C9J2V4 ENST00000420288.1 ENST00000435855.5 ENST00000625706.1 ENST00000626222.2 ENST00000428592.1 ENST00000627618.1 Q3KR05 ENST00000415936.5 Q8WWR8 C9J5X2 ENST00000621851.4 [Q8WWR8-1] C9JRN9 F8WE58 ENST00000627724.2 ENST00000405370.5 [Q8WWR8-1] ENST00000426032.5 ENST00000616490.3 [Q8WWR8-2] ENST00000435894.5 ENST00000423583.5 C9JEA3 ENST00000626195.1 C9J295 ENST00000407683.6 [Q8WWR8-1] C9IZG9 ENST00000629646.2 ENST00000391969.6 [Q8WWR8-1] ENST00000618866.4 [Q8WWR8-1] C9J2R4 B3KR54 ENST00000626600.2 [Q8WWR8-3] ENST00000435934.1 ENST00000629521.2 ENST00000325935.10 [Q8WWR8-3] |
